Xcviii . Studies on the Metabolism of Pyruvic Acid in Normal and Vitamin B 1 - Deficient States
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Clxxxviii. Studies on the Metabolism of Pyruvic Acid in Normal and Vitamin B1-deficient States v. the Effect of Exercise on Blood Pyruvate in Vitamin B1 Deficiency in Man
FOLLOWING the establishment [Platt & Lu, 1939] of the occurrence of increased amounts of pyruvic acid in the body fluids of patients suffering from beri-beri and the studies of Lu [1939] on the effect of muscular activity on the blood pyruvate of the rabbit, it appeared desirable that an investigation should be made of the relationships between pyruvic acid accumulation in the blood, amount of ...
متن کاملLxxx. Blood Pyruvate in Vitamin B1 Deficiency
IN the course of recent work on the role of vitamin B, in the metabolism of brain, it was discovered [Peters and Sinclair, 1933] that lactate solutions in which avitaminous pigeon's brain cells had respired for 2 hours gave a positive nitroprusside reaction for pyruvic acid [Simon and Piaux, 1924]. This led to a quantitative investigation of the formation of pyruvic acid during the respiration ...
متن کاملThe Bisulphite-Binding Power of the Blood in Cases of Epidemic Dropsy, Anæmia and Malaria and Its Possible Bearing on a Vitamin-B Deficiency
Peters and Sinclair (1933) have shown that in pigeons suffering from vitamin-B, deficiency the brain, when incubated with lactic acid, produced pyruvic acid in appreciable amount whereas when the brain of normal control birds is substituted this is not produced. Peters and Thompson (1934) further showed that pyruvic acid is probably a normal intermediary in the course of carbohydrate metabolism...
متن کاملThie Relationship of the Blood Pyruvic Acid Level to Deficiency States in Infancy and Childhood
Thiamin, acting in the form of its phosphoric ester co-carboxylase, is an enzyme necessary for the complete metabolism of glucose. In its absence glucose is broken down as far as pyruvic acid, which then accumulates until vitamin B1 is supplied. Peters and Thompson (1934) and Peters (1936) demonstrated that the respiration of avitaminotic pigeon brain was reduced as compared with that of normal...
متن کاملThe relationship of the blood pyruvic acid level to deficiency states in infancy and childhood.
Thiamin, acting in the form of its phosphoric ester co-carboxylase, is an enzyme necessary for the complete metabolism of glucose. In its absence glucose is broken down as far as pyruvic acid, which then accumulates until vitamin B1 is supplied. Peters and Thompson (1934) and Peters (1936) demonstrated that the respiration of avitaminotic pigeon brain was reduced as compared with that of normal...
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